Zebrafish Research | Behind the Scenes of the Johns Hopkins Zebrafish Facility - YouTube
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00:00:01 00:00:02 (happy music)
00:00:02 00:00:05 >> This is the Johns Hopkins Zebrafish Facility.
00:00:05 00:00:07 We're a core facility that provides housing
00:00:07 00:00:12 and care for the zebrafish for four labs here on campus
00:00:12 00:00:14 that do their own projects and research
00:00:14 00:00:15 using the fish that are kept here.
00:00:15 00:00:19 Almost all of the major organs that human beings have,
00:00:19 00:00:22 the zebrafish has the same organs.
00:00:22 00:00:24 And most of them work the same way
00:00:24 00:00:25 as they do in a human being.
00:00:25 00:00:28 >> So zebrafish are an excellent model organism
00:00:28 00:00:29 to use for developmental biology
00:00:29 00:00:32 because we can actually watch the process
00:00:32 00:00:34 from a single cell animal,
00:00:34 00:00:36 all the way up until the developed fish.
00:00:36 00:00:38 When they're born, they're in a translucent egg,
00:00:38 00:00:41 and so we can watch them from the minute they're released
00:00:41 00:00:44 from the mother, up until they become a full fish.
00:00:44 00:00:46 So what I really like about zebrafish
00:00:46 00:00:49 and developmental biology, is that we can use it to study
00:00:49 00:00:51 how an organism forms.
00:00:51 00:00:52 And that can apply to things
00:00:52 00:00:54 like congenital defects in humans,
00:00:54 00:00:57 and understanding how we can fix
00:00:57 00:00:59 early-onset pediatric illnesses.
00:01:05 00:01:07 >> A lot of the studies, actually, that are done here
00:01:07 00:01:10 are based on the zebrafish's ability to regenerate.
00:01:10 00:01:14 So you could cut the pancreas out of a zebrafish,
00:01:14 00:01:18 and a few days later, it will be growing a new pancreas,
00:01:18 00:01:21 which is something that a human being cannot do.
00:01:21 00:01:25 >> So I have been working in the labs of Mike Parsons
00:01:25 00:01:26 and Jeff Mumm.
00:01:26 00:01:28 We have been comparing the zebrafish pancreas
00:01:28 00:01:31 to the human pancreas, and there are many similarities.
00:01:31 00:01:34 And we know that the cell type in the zebrafish
00:01:34 00:01:37 that we think is responsible for regenerating
00:01:37 00:01:39 the endocrine cells of the pancreas exists in humans,
00:01:39 00:01:41 it just doesn't regenerate.
00:01:41 00:01:43 So if we could figure out what that difference is,
00:01:43 00:01:46 we could high-jack that system in humans.
00:01:46 00:01:49 (happy music)
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